Isaacs himself is bitten and he retreats to the Umbrella base where, in an effort to cure himself, he injects himself with large doses of the anti-virus, which causes him to transform into a , a towering creature with regenerative ability and psionic psychic powers similar to Alice's.
The complex computer The Red Queen shuts down the base to prevent from infection.
That's just the precursor to an even bigger lockdown that doesn't make sense.
In December 2018, was hired as writer and director.
Then Rain shoots her with a machine gun.
The addition of the rail could have been made to give modernity to the old 1911 design.