With being a living totem of the Mind Stone and being one for the Space Stone, it seems all but inevitable for the Stones to return at some point, or at least their energies.
Consequently, what does Thanos say when he snaps his fingers in Infinity War? He got Mad and gave Thanos the chance to escape the grasp of the Avengers and snapped half of the universe out of existence.
In a situation where the only way to win requires multiple decisions that end negatively, it's difficult to blame one person.
Recovering from his injury, Thanos, much to Thor's horror, snapped his fingers to activate the Infinity Gauntlet then passed out.
Many parents and guardians watch their kids turn to dust before them.
In addition to that, it honors creators like Starlin, Stan Lee, Steve Ditko, and Jack Kirby among others who laid the storytelling foundation of the Marvel universe as well.