Therefore, it is advised that Pyrazinamide be used with caution in nursing mothers taking into account the risk-benefit of this therapy.
Such a mechanism of action provides the best explanation for the unusual properties of pyrazinamide, such as the acid pH requirement, the slow killing and relatively high MIC for young growing bacilli with more energy reserves, and the preferential activity against old non-replicating bacilli with less energy reserves.
Moderate Careful monitoring of hepatic function is recommended with the concurrent use of rifampin and pyrazinamide, PZA.